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how statins may cause and/or worsen spinal stenois
2005-07-30 09:41:16
Statins may cause and/or worsen spinal stenosis. This study indicates
STATINS promote bone formation. Stenosis is new bone formation (thickned bone) and possible attendent nerve compression in the spinal nerve canal. Zee http://www.ncbi.nlm.nih.gov/en trez/query.fcgi?cmd=Retrieve&d b=pubmed&... "New bone formation and bone thickness were significantly enhanced following simvastatin treatment." Biomaterials. 2005 Oct;26(29):5783-9. Promotion of bone formation by simvastatin in polyethylene particle-induced osteolysis. von Knoch F, Wedemeyer C, Heckelei A, Saxler G, Hilken G, Brankamp J, Sterner T, Landgraeber S, Henschke F, Loer F, von Knoch M. Department of Orthopaedic Surgery, Kantonsspital Chur, Loestrasse 170, 7000 Chur, Switzerland. fabianvonkn...@yahoo.com The effcts of statins on bone formation in periprosthetic osteolysis have not been determined to date. We investigated the effect of the HMG-CoA reductase inhibitor simvastatin on osteoblastic bone formation under conditions of ultra-high molecular weight polyethylene (UHMWPE) particle-induced osteolysis. The murine calvarial osteolysis model was utilized in 21 C57BL/J6 mice randomized to three groups. Group I underwent sham surgery only, group II received UHMWPE particles, and group III, particles and simvastatin treatment. After 2 weeks, calvaria were processed for histomorphometry and stained with Giemsa dye. New bone formation was measured as osteoid tissue area within the midline suture. Bone thickness was quantified as indicator of net bone growth. Statistical analysis was performed using one-way ANOVA and a Student's t-test. New bone formation and bone thickness were significantly enhanced following simvastatin treatment. New bone formation was 0.008+/-0.008 mm2 in sham controls (group I), 0.015+/-0.012 mm2 after particle implantation without further intervention (group II), compared to 0.083+/-0.021 mm2 with particle implantation and simvastatin treatment (group III) (p=0.003). The bone thickness was 0.213+/-0.007 mm in group I, 0.183+/-0.005 mm in group II, and 0.238+/-0.009 mm in group III (p=0.00008). In conclusion, simvastatin treatment markedly promoted bone formation and net bone growth in UHMWPE particle-induced osteolysis in a murine calvarial model. These new findings indicate that simvastatin may have favorable osteoanabolic effects on wear debris-mediated osteolysis after total joint arthroplasty, involving local stimulation of osteoblastic bone formation. PMID: 15869791 [PubMed - in process]
2005-07-30 17:34:58
"zee" news:1122741676.803622.92170@z14g2000cwz.googlegroups.com... > Statins may cause and/or worsen spinal stenosis. This study indicates > STATINS promote bone formation. Stenosis is new bone formation > (thickned bone) and possible attendent nerve compression in the spinal > nerve canal. Zee spinal stenosis is NOT new bone formation..but a narrowing of the vertebral column...causing years and years to develop..and yes,,can eventually cause nerve root compression and pain it cannot ..does not..occur or worsen in three months of ANY drug therapy.... > > > > http://www.ncbi.nlm.nih.gov/en trez/query.fcgi?cmd=Retrieve&d > b=pubmed&... > > "New bone formation and bone thickness were significantly enhanced > following simvastatin treatment." > > Biomaterials. 2005 Oct;26(29):5783-9. > Promotion of bone formation by simvastatin in polyethylene > particle-induced osteolysis. > > von Knoch F, Wedemeyer C, Heckelei A, Saxler G, Hilken G, Brankamp J, > Sterner T, Landgraeber S, Henschke F, Loer F, von Knoch M. > > Department of Orthopaedic Surgery, Kantonsspital Chur, Loestrasse 170, > 7000 Chur, Switzerland. fabianvonkn...@yahoo.com > > The effcts of statins on bone formation in periprosthetic osteolysis > have not been determined to date. We investigated the effect of the > HMG-CoA reductase inhibitor simvastatin on osteoblastic bone formation > under conditions of ultra-high molecular weight polyethylene (UHMWPE) > particle-induced osteolysis. The murine calvarial osteolysis model was > utilized in 21 C57BL/J6 mice randomized to three groups. > > Group I underwent sham surgery only, group II received UHMWPE > particles, and group III, particles and simvastatin treatment. After 2 > weeks, calvaria were processed for histomorphometry and stained with > Giemsa dye. New bone formation was measured as osteoid tissue area > within the midline suture. Bone thickness was quantified as indicator > of net bone growth. Statistical analysis was performed using one-way > ANOVA and a Student's t-test. > > New bone formation and bone thickness were significantly enhanced > following simvastatin treatment. > > New bone formation was 0.008+/-0.008 mm2 in sham controls (group I), > 0.015+/-0.012 mm2 after particle implantation without further > intervention (group II), compared to 0.083+/-0.021 mm2 with particle > implantation and simvastatin treatment (group III) (p=0.003). The bone > thickness was 0.213+/-0.007 mm in group I, 0.183+/-0.005 mm in group > II, and 0.238+/-0.009 mm in group III (p=0.00008). > > In conclusion, simvastatin treatment markedly promoted bone formation > and net bone growth in UHMWPE particle-induced osteolysis in a murine > calvarial model. These new findings indicate that simvastatin may have > favorable osteoanabolic effects on wear debris-mediated osteolysis > after total joint arthroplasty, involving local stimulation of > osteoblastic bone formation. > > PMID: 15869791 [PubMed - in process] >
2005-07-30 10:36:02
"zee" news:1122741676.803622.92170@z14g2000cwz.googlegroups.com... > Statins may cause and/or worsen spinal stenosis. This study indicates > STATINS promote bone formation. Stenosis is new bone formation > (thickned bone) and possible attendent nerve compression in the spinal > nerve canal. Zee > That study has nothing to do with your premise that it causes nerve compression. You have turned into an ambulance chaser competing with lawyers now.
2005-07-30 23:53:15
Couldn't this be read as how statins may prevent bone fractures in the aging?
Bill "zee" news:1122741676.803622.92170@z14g2000cwz.googlegroups.com... > Statins may cause and/or worsen spinal stenosis. This study indicates > STATINS promote bone formation. Stenosis is new bone formation > (thickned bone) and possible attendent nerve compression in the spinal > nerve canal. Zee > > > > http://www.ncbi.nlm.nih.gov/en trez/query.fcgi?cmd=Retrieve&d > b=pubmed&... > > "New bone formation and bone thickness were significantly enhanced > following simvastatin treatment." > > Biomaterials. 2005 Oct;26(29):5783-9. > Promotion of bone formation by simvastatin in polyethylene > particle-induced osteolysis. > > von Knoch F, Wedemeyer C, Heckelei A, Saxler G, Hilken G, Brankamp J, > Sterner T, Landgraeber S, Henschke F, Loer F, von Knoch M. > > Department of Orthopaedic Surgery, Kantonsspital Chur, Loestrasse 170, > 7000 Chur, Switzerland. fabianvonkn...@yahoo.com > > The effcts of statins on bone formation in periprosthetic osteolysis > have not been determined to date. We investigated the effect of the > HMG-CoA reductase inhibitor simvastatin on osteoblastic bone formation > under conditions of ultra-high molecular weight polyethylene (UHMWPE) > particle-induced osteolysis. The murine calvarial osteolysis model was > utilized in 21 C57BL/J6 mice randomized to three groups. > > Group I underwent sham surgery only, group II received UHMWPE > particles, and group III, particles and simvastatin treatment. After 2 > weeks, calvaria were processed for histomorphometry and stained with > Giemsa dye. New bone formation was measured as osteoid tissue area > within the midline suture. Bone thickness was quantified as indicator > of net bone growth. Statistical analysis was performed using one-way > ANOVA and a Student's t-test. > > New bone formation and bone thickness were significantly enhanced > following simvastatin treatment. > > New bone formation was 0.008+/-0.008 mm2 in sham controls (group I), > 0.015+/-0.012 mm2 after particle implantation without further > intervention (group II), compared to 0.083+/-0.021 mm2 with particle > implantation and simvastatin treatment (group III) (p=0.003). The bone > thickness was 0.213+/-0.007 mm in group I, 0.183+/-0.005 mm in group > II, and 0.238+/-0.009 mm in group III (p=0.00008). > > In conclusion, simvastatin treatment markedly promoted bone formation > and net bone growth in UHMWPE particle-induced osteolysis in a murine > calvarial model. These new findings indicate that simvastatin may have > favorable osteoanabolic effects on wear debris-mediated osteolysis > after total joint arthroplasty, involving local stimulation of > osteoblastic bone formation. > > PMID: 15869791 [PubMed - in process] >
2005-07-30 17:01:07
Bill wrote: > Couldn't this be read as how statins may prevent bone fractures in the aging? > > Bill Certainly they are going to look for ways to use this. But statins are not a good bet in the aging, particularly if they don't have cardiovascular disease. There is too much risk to the risk/benefit ratio. Zee > "zee" > news:1122741676.803622.92170@z14g2000cwz.googlegroups.com... > > Statins may cause and/or worsen spinal stenosis. This study indicates > > STATINS promote bone formation. Stenosis is new bone formation > > (thickned bone) and possible attendent nerve compression in the spinal > > nerve canal. Zee > > > > > > > > http://www.ncbi.nlm.nih.gov/en trez/query.fcgi?cmd=Retrieve&d > > b=pubmed&... > > > > "New bone formation and bone thickness were significantly enhanced > > following simvastatin treatment." > > > > Biomaterials. 2005 Oct;26(29):5783-9. > > Promotion of bone formation by simvastatin in polyethylene > > particle-induced osteolysis. > > > > von Knoch F, Wedemeyer C, Heckelei A, Saxler G, Hilken G, Brankamp J, > > Sterner T, Landgraeber S, Henschke F, Loer F, von Knoch M. > > > > Department of Orthopaedic Surgery, Kantonsspital Chur, Loestrasse 170, > > 7000 Chur, Switzerland. fabianvonkn...@yahoo.com > > > > The effcts of statins on bone formation in periprosthetic osteolysis > > have not been determined to date. We investigated the effect of the > > HMG-CoA reductase inhibitor simvastatin on osteoblastic bone formation > > under conditions of ultra-high molecular weight polyethylene (UHMWPE) > > particle-induced osteolysis. The murine calvarial osteolysis model was > > utilized in 21 C57BL/J6 mice randomized to three groups. > > > > Group I underwent sham surgery only, group II received UHMWPE > > particles, and group III, particles and simvastatin treatment. After 2 > > weeks, calvaria were processed for histomorphometry and stained with > > Giemsa dye. New bone formation was measured as osteoid tissue area > > within the midline suture. Bone thickness was quantified as indicator > > of net bone growth. Statistical analysis was performed using one-way > > ANOVA and a Student's t-test. > > > > New bone formation and bone thickness were significantly enhanced > > following simvastatin treatment. > > > > New bone formation was 0.008+/-0.008 mm2 in sham controls (group I), > > 0.015+/-0.012 mm2 after particle implantation without further > > intervention (group II), compared to 0.083+/-0.021 mm2 with particle > > implantation and simvastatin treatment (group III) (p=0.003). The bone > > thickness was 0.213+/-0.007 mm in group I, 0.183+/-0.005 mm in group > > II, and 0.238+/-0.009 mm in group III (p=0.00008). > > > > In conclusion, simvastatin treatment markedly promoted bone formation > > and net bone growth in UHMWPE particle-induced osteolysis in a murine > > calvarial model. These new findings indicate that simvastatin may have > > favorable osteoanabolic effects on wear debris-mediated osteolysis > > after total joint arthroplasty, involving local stimulation of > > osteoblastic bone formation. > > > > PMID: 15869791 [PubMed - in process] > >
2005-07-30 19:22:23
Hawki,
I'm a little confused. How can the study get valid measurable results, sufficient to pass the editorial jury of peers and get into print, after reportedly only 2 weeks? Also, how can we be certain that the thickening of a bone would be only on the outside? If a donut shaped bone thickened, might it not thicken throughout and thereby reduce the diameter of the 'donut hole'? Did the paper specify? Do you have access to the full text version? news:6TOGe.8379$_%4.4451@newssvr14.news.prodigy.com... > > "zee" > news:1122741676.803622.92170@z14g2000cwz.googlegroups.com... >> Statins may cause and/or worsen spinal stenosis. This study indicates >> STATINS promote bone formation. Stenosis is new bone formation >> (thickned bone) and possible attendent nerve compression in the spinal >> nerve canal. Zee > > spinal stenosis is NOT new bone formation..but a narrowing of the > vertebral column...causing years and years to develop..and yes,,can > eventually cause nerve root compression and pain > > it cannot ..does not..occur or worsen in three months of ANY drug > therapy.... >> >> >> >> http://www.ncbi.nlm.nih.gov/en trez/query.fcgi?cmd=Retrieve&d >> b=pubmed&... >> >> "New bone formation and bone thickness were significantly enhanced >> following simvastatin treatment." >> >> Biomaterials. 2005 Oct;26(29):5783-9. >> Promotion of bone formation by simvastatin in polyethylene >> particle-induced osteolysis. >> >> von Knoch F, Wedemeyer C, Heckelei A, Saxler G, Hilken G, Brankamp J, >> Sterner T, Landgraeber S, Henschke F, Loer F, von Knoch M. >> >> Department of Orthopaedic Surgery, Kantonsspital Chur, Loestrasse 170, >> 7000 Chur, Switzerland. fabianvonkn...@yahoo.com >> >> The effcts of statins on bone formation in periprosthetic osteolysis >> have not been determined to date. We investigated the effect of the >> HMG-CoA reductase inhibitor simvastatin on osteoblastic bone formation >> under conditions of ultra-high molecular weight polyethylene (UHMWPE) >> particle-induced osteolysis. The murine calvarial osteolysis model was >> utilized in 21 C57BL/J6 mice randomized to three groups. >> >> Group I underwent sham surgery only, group II received UHMWPE >> particles, and group III, particles and simvastatin treatment. After 2 >> weeks, calvaria were processed for histomorphometry and stained with >> Giemsa dye. New bone formation was measured as osteoid tissue area >> within the midline suture. Bone thickness was quantified as indicator >> of net bone growth. Statistical analysis was performed using one-way >> ANOVA and a Student's t-test. >> >> New bone formation and bone thickness were significantly enhanced >> following simvastatin treatment. >> >> New bone formation was 0.008+/-0.008 mm2 in sham controls (group I), >> 0.015+/-0.012 mm2 after particle implantation without further >> intervention (group II), compared to 0.083+/-0.021 mm2 with particle >> implantation and simvastatin treatment (group III) (p=0.003). The bone >> thickness was 0.213+/-0.007 mm in group I, 0.183+/-0.005 mm in group >> II, and 0.238+/-0.009 mm in group III (p=0.00008). >> >> In conclusion, simvastatin treatment markedly promoted bone formation >> and net bone growth in UHMWPE particle-induced osteolysis in a murine >> calvarial model. These new findings indicate that simvastatin may have >> favorable osteoanabolic effects on wear debris-mediated osteolysis >> after total joint arthroplasty, involving local stimulation of >> osteoblastic bone formation. >> >> PMID: 15869791 [PubMed - in process] >> > >
2005-07-31 20:07:15
"Sharon Hope" news:nYSdnWoIh4tCqHHfRVn-vg@comcast.com... > Hawki, > > I'm a little confused. How can the study get valid measurable results, > sufficient to pass the editorial jury of peers and get into print, after > reportedly only 2 weeks? it was a preliminary study...very preliminary... > > Also, how can we be certain that the thickening of a bone would be only on > the outside? If a donut shaped bone thickened, might it not thicken > throughout and thereby reduce the diameter of the 'donut hole'? theoritically...it could...however..this abstract was sooo short and statistically insignificant..who knows?? again..spinal stenosis takes YEARS to develop and years to worsen..Rita's situation involved taking statins for a mere 3.5 months..significant bone growth enough to cause her symptom changes...are unlikely.. > > Did the paper specify? Do you have access to the full text version? the paper specified WHERE this new bone growth occurred and was measured... it specified (which Zee quoted but did not comment upon) "These new findings indicate that simvastatin MAY have favorable osteoanabolic effects on wear debris mediated osteolysis AFTER total joint arthroplasty,,involving local stimulation of osteoblastic bone formation" comments: note the MAY have .....snip note also that this study ONLY after total joint etc etc in other words...it may not have been the statins AT ALL...as ALL joint replacements begin to build new bones at the "midline suture" (quote from the abstract)..even WITHOUT any added meds...this is the physiology of how joint replacements work surely at the two week mark..it is impossible to conclude that it WAS the statins added that accounted for the change..in fact..note that the difference was less than signifcance level which is .05...so even if there WAS a difference it was minute..and can be attributed to other issues..ie age and health of the patient..etc > > > > news:6TOGe.8379$_%4.4451@newssvr14.news.prodigy.com... >> >> "zee" >> news:1122741676.803622.92170@z14g2000cwz.googlegroups.com... >>> Statins may cause and/or worsen spinal stenosis. This study indicates >>> STATINS promote bone formation. Stenosis is new bone formation >>> (thickned bone) and possible attendent nerve compression in the spinal >>> nerve canal. Zee >> >> spinal stenosis is NOT new bone formation..but a narrowing of the >> vertebral column...causing years and years to develop..and yes,,can >> eventually cause nerve root compression and pain >> >> it cannot ..does not..occur or worsen in three months of ANY drug >> therapy.... >>> >>> >>> >>> http://www.ncbi.nlm.nih.gov/en trez/query.fcgi?cmd=Retrieve&d >>> b=pubmed&... >>> >>> "New bone formation and bone thickness were significantly enhanced >>> following simvastatin treatment." >>> >>> Biomaterials. 2005 Oct;26(29):5783-9. >>> Promotion of bone formation by simvastatin in polyethylene >>> particle-induced osteolysis. >>> >>> von Knoch F, Wedemeyer C, Heckelei A, Saxler G, Hilken G, Brankamp J, >>> Sterner T, Landgraeber S, Henschke F, Loer F, von Knoch M. >>> >>> Department of Orthopaedic Surgery, Kantonsspital Chur, Loestrasse 170, >>> 7000 Chur, Switzerland. fabianvonkn...@yahoo.com >>> >>> The effcts of statins on bone formation in periprosthetic osteolysis >>> have not been determined to date. We investigated the effect of the >>> HMG-CoA reductase inhibitor simvastatin on osteoblastic bone formation >>> under conditions of ultra-high molecular weight polyethylene (UHMWPE) >>> particle-induced osteolysis. The murine calvarial osteolysis model was >>> utilized in 21 C57BL/J6 mice randomized to three groups. >>> >>> Group I underwent sham surgery only, group II received UHMWPE >>> particles, and group III, particles and simvastatin treatment. After 2 >>> weeks, calvaria were processed for histomorphometry and stained with >>> Giemsa dye. New bone formation was measured as osteoid tissue area >>> within the midline suture. Bone thickness was quantified as indicator >>> of net bone growth. Statistical analysis was performed using one-way >>> ANOVA and a Student's t-test. >>> >>> New bone formation and bone thickness were significantly enhanced >>> following simvastatin treatment. >>> >>> New bone formation was 0.008+/-0.008 mm2 in sham controls (group I), >>> 0.015+/-0.012 mm2 after particle implantation without further >>> intervention (group II), compared to 0.083+/-0.021 mm2 with particle >>> implantation and simvastatin treatment (group III) (p=0.003). The bone >>> thickness was 0.213+/-0.007 mm in group I, 0.183+/-0.005 mm in group >>> II, and 0.238+/-0.009 mm in group III (p=0.00008). >>> >>> In conclusion, simvastatin treatment markedly promoted bone formation >>> and net bone growth in UHMWPE particle-induced osteolysis in a murine >>> calvarial model. These new findings indicate that simvastatin may have >>> favorable osteoanabolic effects on wear debris-mediated osteolysis >>> after total joint arthroplasty, involving local stimulation of >>> osteoblastic bone formation. >>> >>> PMID: 15869791 [PubMed - in process] >>> >> >> > >
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